Biotech

Elevenostat: Don't Believe the Label

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Based on a feed excerpt; full article content has not been acquired. Source evidence retrieved 22/10/2026, 18:19:31 UTC.

Briefings

A 2026 article warns that elevenostat is not a selective HDAC11 probe but primarily binds HDAC6 and HDAC10 with nanomolar affinity, contradicting prior literature. The author notes the compound was previously labeled as selective for HDAC11, but binding data shows weak HDAC11 activity (10 micromolar) compared to stronger binding at other HDACs. The article advises researchers to verify probe specificity through binding profiles rather than relying on supplier labels.

Key points

• elevenostat binds HDAC6 and HDAC10 with single-digit nanomolar affinity, whereas its HDAC11 binding is weak at 10 micromolar.
• The compound was previously labeled as a selective HDAC11 inhibitor, but binding data contradicts this label.

Context

This article challenges established chemical probe usage by revealing that elevenostat's biological activity aligns more closely with HDAC6 and HDAC10 mechanisms rather than HDAC11. The author emphasizes that tight-binding compounds often utilize zincophore head groups, making selectivity difficult to achieve across multiple HDAC isoforms. The article serves as a cautionary note for researchers relying on supplier labels without independent verification.

Limitations

The evidence is limited to a single article from 2026. Specific binding constants for HDAC11 were not measured in the provided text, only the 10 micromolar value is cited. The article does not provide experimental data or direct measurements of the compound's activity against HDAC11, only its theoretical binding affinity.

Generated by Bittrees-hosted qwen35-2b sha256:aaf42c8b7c3c on 22/10/2026, 19:00:23 UTC. Based on publisher-provided feed evidence; may not cover the full original article. Check the source for details.

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