Science

Physicists reveal new paradigm for fiber growth in neurodegenerative diseases

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Based on a feed excerpt; full article content has not been acquired. Source evidence retrieved 26/10/2026, 15:55:25 UTC.

Briefings

Leiden physicists Liru Feng and Louise Jawerth discovered a mechanism where neurodegenerative proteins transition between liquid droplets and solid amyloid fibers, challenging previous models of disease progression. This finding suggests a dynamic interplay between these states rather than a static transformation, potentially offering new therapeutic targets for conditions like Alzheimer's and Parkinson's.

Key points

• Leiden physicists Liru Feng and Louise Jawerth discovered a mechanism where neurodegenerative proteins transition between liquid droplets and solid amyloid fibers.
• The discovery challenges previous models by suggesting a dynamic interplay between these states rather than a static transformation.

Context

This research addresses a critical gap in understanding how protein misfolding leads to neurodegeneration, potentially offering new therapeutic targets for conditions like Alzheimer's and Parkinson's.

Limitations

Evidence is limited to a single study by Feng and Jawerth at Leiden University. The study does not provide causal claims or specific dates for disease onset, and the mechanism remains unproven in human trials.

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