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The DEA banned a drug some opioid users called a miracle

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Briefings

In 2017, Laura Bohn and her team at the University of South Florida Health, funded by the National Institute on Drug Abuse, published findings in the journal Cell identifying SR-17018 as a potential pain reliever for mice. The study revealed that SR-17018 could manage pain without causing respiratory depression, a critical safety advantage over opioids. The researchers discovered the compound did not induce high tolerance in mice and allowed dependent mice to reset their tolerance without withdrawal pain. This research was a pivotal step in the search for safer alternatives to opioids.

Key points

• Laura Bohn and her team at the University of South Florida Health published findings in the journal Cell in 2017 identifying SR-17018 as a pain reliever for mice without respiratory depression.
• The compound did not induce high tolerance in mice and allowed dependent mice to reset their tolerance without withdrawal pain.

Context

This research represents a significant advancement in pain management research, specifically addressing the safety concerns associated with opioid use. The study was funded by the National Institute on Drug Abuse and aimed to identify safer alternatives to opioids.

Limitations

The evidence is limited to a 2017 study published in the journal Cell involving mice. The study does not include human clinical trials, and the specific efficacy of SR-17018 in humans remains unverified. The findings are observational and do not constitute a direct recommendation for clinical use.

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