Health

All of Us study finds thousands of new genetic variants affecting drug responses

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Based on a feed excerpt; full article content has not been acquired. Source evidence retrieved 11/11/2026, 22:36:24 UTC.

Briefings

A 2026 study of nearly 100,000 Americans using the All of Us program identified thousands of new genetic variants affecting drug responses across 16 pharmacogenes. The research highlighted that one in four participants had taken medications influenced by these variants, expanding the scope beyond previous studies with more diverse ancestries.

Key points

• The study analyzed nearly 100,000 participants from the All of Us program to identify new genetic variants in 16 pharmacogenes.
• One in four participants had taken medications affected by these variants, with every participant carrying at least one variant in the studied set.

Context

This research expands on prior pharmacogenetic studies by incorporating a more diverse set of ancestries, potentially improving drug response predictions for broader populations.

Limitations

The evidence is limited to the 16 pharmacogenes studied in this specific analysis; the study does not provide causal claims or forecasts about future drug outcomes.

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