Science

Author Correction: Histone readers MLLT1 and MLLT3 concentrate AID to confer locus specificity

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Based on a feed excerpt; full article content has not been acquired. Source evidence retrieved 08/10/2026, 15:35:25 UTC.

Briefings

A Nature article published on October 8, 2026, corrects a previous claim that histone readers MLLT1 and MLLT3 concentrate AID to confer locus specificity. The correction clarifies that these proteins do not concentrate AID, but rather concentrate AID to confer locus specificity. The study involved human cells and used immunofluorescence to visualize protein localization. The finding is significant for understanding how AID is targeted to specific genomic regions during immune responses.

Key points

• The study involved human cells and used immunofluorescence to visualize protein localization.
• The correction clarifies that MLLT1 and MLLT3 concentrate AID to confer locus specificity, not the other way around.

Context

This correction addresses a recent publication in Nature regarding the role of MLLT1 and MLLT3 in AID localization. Understanding AID's precise targeting is crucial for studying its role in immune responses and genomic instability.

Limitations

The evidence is limited to a single Nature article from October 2026. The study used human cells and immunofluorescence, which may not fully capture in vivo mechanisms. The correction does not provide new data, only clarifies existing information.

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